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Clozapine was first shown to be superior to chlorpromazine (Thorazine) in patients who had inadequate response to at least 3 first-generation antipsychotics (Kane J et al, Arch Gen Psych 1988;45(9):789796)
6 Context Since 2000, cigarette smoking by youth in the United States has decreased from 23% to less than 5%
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