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Despite finding no morphological differences in the sizes of the placental layers, we identified numerous changes in placental gene expression

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The sudden obstruction of blood circulation rapidly introduces a hypoxic and nutrient-deprived condition in the adjacent brain region, initiating several pathophysiological secondary injury pathways that progress with time, ultimately impairing intracellular homeostasis and resulting in a localized cerebral infarction (Heiss et al., 1999