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Both intravenous nicotine and aerosolized nicotine self-administration assays have been established for both rats and mice (6167)

Typically, if you want a more realistic smoking sensation, you will most likely want to use a vape pen and a nicotine liquid with a higher PG content

Meyers D G, J S Neuberger, and J He (2009), Cardiovascular Effect of Bans on Smoking in Public Places: A Systematic Review and Meta-Analysis, Journal of the American College of Cardiology 54: 1249- 1255

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