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Here, we use single-cell RNA-sequencing (scRNA-seq) to define the transcriptional cell types and states of the tracheal airway epithelium in smokers and non-smokers, infer the lineage relationships among these cells, and determine the influence of cigarette smoke on individual surface and SMG airway epithelial cell types with single-cell resolution

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Alice Cooper became the band and the man, the two fused in an explosion of rocknroll outrage that has spanned four decades and lays claim to the accidental invention of glam and punk, and the intentional invention of shock rock a free-form riot of excess that has, over the years, involved mind-scrambling acts of self-evisceration and infanticide (fake) and heart-stopping acts of chemical bravado and liquid insanity (real), all wrapped around razor-sharp slices of downtown glitter punk that spoke of cheerful subjects like sex with the dead and serial murder