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It is not designed for use with tobacco that is long or has excessive moisture content.

It is associated with the respiratory disease known as popcorn lung. Cinnamaldehyde, a cinnamon flavoring that, when inhaled, has been shown to impair respiratory immune cells

There was high certainty that quit rates were higher in people randomized to nicotine e-cigarettes than in those randomized to nicotine replacement therapy (risk ratio [RR]1.63, 95% confidence interval [CI] 1.30 to 2.04) and moderate-certainty evidence, limited by imprecision, that quit rates were higher in people randomized to nicotine e-cigarettes than to e-cigarettes without nicotine (RR 1.94, 95% CI 1.21 to 3.13)