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Am J Psychiat 152 : 453455 Decina P, Caracci G, Sandik R, Berman W, Mukherjee S, Scapicchio P

[cited 2024 Sept 2]

Despite the various measures and initiatives taken up by the Ministry of Social Justice and Empowerment of India to reduce drug abuse, the incidence continues to grow

Why Your Body Holds Onto Nicotine (And Why It Matters) The Two-Phase Problem Nobody Explains When you use nicotinewhether from cigarettes, vapes, pouches, or gumyour body immediately begins a two-phase process: Phase 1: Nicotine Processing (1-4 hours) Nicotine hits your bloodstream Half-life of 1-2 hours (50% gone) Liver converts it to cotinine You feel the effects wearing off Phase 2: Cotinine Clearance (Days to Weeks) Cotinine half-life: 16-20 hours Stores in fat cells, organs, and hair What drug tests actually measure Determines your "clean" timeline The Metabolite That Ruins Everything: Cotinine Here's the plot twist: nicotine tests don't test for nicotine