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19702022) and life expectancy (19702021) in individuals aged 20 years and older by year, sex, race, and age were obtained from the Centers for Disease Control and Prevention's National Center for Health Statistics, which provides complete coverage of the US population

Since 1964, when the US Surgeon General released the first report on smoking and health, the smoking rate among US adults has fallen to 18 percent from 42 percent, as of data released in 2014

Trends in smoking-attributable and smoking-unrelated lung cancer death rates in the U.S., 1991-2018

We also examined the microbiome associated with tobacco products and the microbiome in different groups of oral sample sites (healthy buccal site, OSCC buccal site, TC-H, NTC-H, OSCC-T-site, OSCC-B-site)