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It is also recognized that smoke exposure leads to the activation of the Nod-like receptor protein 3 (NLRP3) inflammasome [63], with consequent local generation of active interleukin 1 (IL-1), a process that induces inflammation and thereby can lead to both chronic fibrosis and cancer in mice [64]

Tar, not nicotine, is the chemical in cigarettes that is most linked to cancer but that doesnt mean nicotine is good for you

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To open the lid, pull the tab in the direction as shown in the illustration