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Comparisons of more than two groups were performed using analysis of variance (ANOVA) with Tukeys test

these positive effectors increase manifold the affinity of ketoglutarate dehydrogenase complex to alpha-ketoglutarate

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The mechanism of action of this class of drugs is to inhibit the expression of type 5 phosphodiesterase (PDE5) in the cavernous body, then increase the concentration of cGMP in vascular smooth muscle cells, then reduce intracellular Ga2+ and cause smooth muscle relaxation, then increase the blood flow of the cavernous body, and thus improve ED (Montorsi et al