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Major vascular complications were defined as stroke, angiographically-documented coronary artery disease or a myocardial infarction
In one of such studies by Ldicke et al., 8 biomarkers were assessed: HDL-C, white blood cell (WBC), forced expiratory volume in one second (FEV1) post-bronchodilator, expressed as % predicted (FEV1%pred), carboxyhemoglobin (COHb) in blood, total 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (Total NNAL), soluble intercellular adhesion molecule-1 (sICAM-1) in serum, 11 dehydrothromboxane B2 (11-DTX-B2), 8-epi-prostaglandin F2 alpha (8-epi-PGF2)
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