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Decisive evidence that increased adipose tissue lipolysis contributes to nicotine plus HFD-induced hepatic steatosis derives from studies showing that acipimox, an inhibitor of adipose tissue lipolysis, treatment significantly prevented nicotine plus HFD-induced increase in hepatic TG levels and hepatic steatosis (Figure 2) (42)

Although these studies were well-conducted, this does not rule out confounding variables and chance completely, as we have learned that any study can be partially due to chance

Exacerbation of Existing Conditions: For individuals with hepatitis B or C, smoking accelerates liver damage, increasing the risk of cirrhosis and liver cancer

This review explores the contribution of nicotine and obesity to the development of NAFLD and its molecular underpinning