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von Euler), Karolinska Institutet, Stockholm, showed that 4-methylnicotine exerted a very low pharmacological activity in all the tests used 1 while that of 6-methylnicotine was fairly strong The stimulating effect of 6-methylnicotine on the isolated guinea-pigs ileum was 25% stronger than that of natural nicotine

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"We have seen a seismic shift," Goldin says, "a tremendous influx of new collectors with high disposable income." To name just one example: A 1968 Topps rookie card of the pitcher Nolan Ryan sold this year for $80,000