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24: 405411 (2009) Naruszewicz M, Zapolska-Downar D, Komider A, Nowicka G, Kozowska-Wojciechowska M, Vikstrm AS, Trnqvist M
Muscle-specific IGF1R knockout mice display disrupted muscle fiber formation and reduced muscle weight early in development ( in vivo ( In vitro , IGF-1 stimulates expression of cellular communication network factor 5 (CCN5) and promotes -cell proliferation ( in vivo , however, silencing IGF-1 in not only the WPMY-1 prostate stroma cell line, and but also BPH-1, a prostate epithelium cell line, decreased cell proliferation and increased apoptosis rate in vitro ( IGF1R is located on the long arm of chromosome 15, and 36 different probable mutations have been reported ( Cancers and IGF-1 Signaling IGF-1 is involved in several diseases
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