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comparable efficacy to duloxetine Disadvantages: Smaller trials
Advanced glycation end products (AGEs) accumulate with age, diabetes, and renal failure, promoting vascular inflammation through the AGE-RAGE axis
Retatrutide (LY3437943) is an investigational triple hormone receptor agonist that activates: GLP-1 (glucagon-like peptide-1) receptor GIP (glucose-dependent insulinotropic polypeptide) receptor Glucagon (GCG) receptor This triple G mechanism targets multiple pathways for appetite control, insulin sensitivity, glucose regulation, and energy/fat metabolismpotentially offering greater effects than dual (GLP-1/GIP) or single agonists
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