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The functional activity of LAG-3 depends on dynamic protein dimerization, which influences both ligand binding and association with the TCR ( Clinical evidence indicates that LAG-3 receptor blockers have a favorable efficacy and safety profile and may offer therapeutic benefit to patients who have exhausted currently available options for histologically confirmed, locally advanced, unresectable, or metastatic solid tumors, particularly when combined with drugs targeting the PD-1 receptor

[66] [67] It was also diffused into East Africa via the Austronesian settlement of Madagascar and the Comoros by around the 7th century

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