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Additionally, brain cholesterol, primarily stored in myelin and neuronal plasma membranes, declines with age, which is associated with synaptic dysfunction and an increased risk of neurodegenerative diseases [244]

755 Mechanistically, SSAT1 overexpression increases ALOX15 expression and decreases the expression levels of GPX4 and SLC7A11 in primary cortical neurons, suggesting that SSAT1/ALOX15 axis activation may aggravate brain I/R injury by triggering ferroptosis in neurons

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Cells The cell lines BEAS-2B, H1975, H1650, A549, H1299, and the engineered primary human lung adenocarcinoma cells pLUAD1 were obtained from the Thoracic Surgery Laboratory at the First Affiliated Hospital of Soochow University