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In the BioCycle Study ( n = 259 premenopausal women), greater isoflavone intake was associated with higher follicular SHBG (+8.6%, p = 0.05) and lower luteal testosterone (14.5%, p = 0.04), with a trend toward reduced sporadic anovulation (HR 0.56, p = 0.07), without impacting E2, P4, FSH, or LH, indicating mild anti-androgenic and SHBG-modulating effects without overt HPO disruption [164]
In the case of GSTs, these multifunctional and essential enzymes are involved in many processes, such as detoxification, signaling, redox homeostasis, plant metabolism, growth regulation, and adaptation to biotic and abiotic stress ( Tobamovirus ( Geminivirus ( Tenuivirus ( A relatively low number of studies have focused on the importance of the glutathione cycle and glutathione-associated enzymes in plant cell responses, both compatible and incompatible, or their potential role in developing resistance to plant viruses
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