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Conversely, Melatonin significantly reduced Iba1 expression levels, potentially through the NF-B and MAPK pathways, which have been identified as key regulators of central sensitization besides the role of pro-inflammatory cytokines, IL-1, and TNF- (Fusco et al

Both terms refer to the same synthetic tetrapeptide composed of four amino acids: alanine, glutamic acid, aspartic acid, and glycine (Ala-Glu-Asp-Gly)

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