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Funding This work was supported by the National Natural Science Foundation of China (Grant 81720108030, 81773695, 81803475, 81373371, and 31871810), National Key Research and Development Project of China (2018YFE0208600), China Postdoctoral Science Foundation, the financial support by Key Lab for Drug Delivery & Tissue Regeneration (SS2018004), Jiangsu Provincial Research Center for Medicinal Function Development of New Food Resources, and a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions

Most side effects diminish significantly within two to four weeks as tolerance develops

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This notable effect results from combined mechanisms that address appetite, satiety, gastric emptying, and glucose body function through multiple receptor systems, creating full effects that exceed simple addition of personal peptide effects