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We think the smooth sumac may have been mixed with tobacco for its medicinal qualities and to improve the flavor of smoke. The discovery was made possible by a new metabolomics-based analysis method that can detect thousands of plant compounds or metabolites in residue collected from ancient pipes, bowls and other artifacts

Much of the available research for snuff and snus is on Swedish populations because the product was initially more available in Sweden

Smoking promotes the transfer of bile salts from the intestines into the stomach, thereby concentrating the stomach acids