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Emerging Evidence on Cancer Risk Factors In addition to epidemiological data on increasing incidence or death from cancers, emerging mechanistic studies indicate how cancer risk factors such as obesity, smoking, and reproductive factors can influence disease subtype, aggressiveness, and outcomes through their effects on cancer cells and/or the tumor microenvironment including immune cells (258)(259)(260)(261)

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By contrast, daily smoking prevalence had steadily reduced between 2011/12 and 2022/23 (from 16.4% to 6.8%)