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Rates of cigarette use have dramatically fallen since a landmark 1964 Surgeon General report warned about the dangers of cigarette smoking and linked it to lung cancer, chronic bronchitis and other serious diseases

Recent evidence also demonstrates the dual role of nicotine, which primarily promotes hepatocarcinogenesis through activation of multiple oncogenic signaling cascades, including 7-nicotinic acetylcholine receptor (7-nAChR)/JAK2/STAT3, CYP1A1/PI3K/Akt signaling mediated by NF-B and AP-1, SETDB1/CDK6-mediated STAT1 stabilization, GCF2-driven Wnt/-catenin/SOX2 signaling, and the 2-adrenergic receptor (2-AR)/PI3K/Akt pathway [35,36,37]

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Remove any cigarette butts and ashtrays Throw away leftover cigarette butts and clean ashtrays thoroughly