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Skin Pharmacol

Studies distinguishing between e-cigarettes with and without nicotine found increases in endothelial progenitor cells, endothelial vesicles, plasma myeloperoxidase, arterial stiffness, changes in nicotine receptors, alveolar macrophages, and mononuclear phagocytes, leading to altered inflammatory responses and increased pulmonary susceptibility in users of nicotine-containing e-cigarettes (29, 41, 46)

I think its also because I come from Benin, the birthplace of voodoo, and, not so much voodoo, but the belief in animism, the belief in spirits is major in Africa

Food and Drug Administration has proposed limiting the amount of nicotine in cigarettes to minimally addictive levels, but there's been concern that the drop in nicotine could exacerbate anxieties in smokers who might already battle mood issues