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2016 European Guidelines on cardiovascular disease prevention in clinical practice: The Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of 10 societies and by invited experts)Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR)

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Studies have shown that inactivation of Nrf2, either through direct knockdown in CKD or indirect knockdown of endothelial nitric oxide synthase (eNOS) in hepatocytes, exacerbated OS and impaired PINK1/Parkin-mediated mitophagy, contributing to the progression of renal and hepatic fibrosis (Sheldon et al., 2019