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Central role of fibroblast alpha3 nicotinic acetylcholine receptor in mediating cutaneous effects of nicotine

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"We believe the FDA authorizing our ability to communicate reduced-risk information to smokers would be a scientifically sound step toward reducing the harm caused by cigarettes and is consistent with the FDA's vision to put in place a comprehensive regulatory framework based on tobacco harm reduction." The Tobacco Control Act prohibits manufacturers from communicating to consumers that any particular product presents less risk than another tobacco product without first obtaining an MRTP marketing order from the FDA