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Studies indicate that MC-1R activation stimulates melanin production in melanocytes, leading to skin darkening effects observed in animal models

Data availability The datasets generated during the current study are available in a Supplementary File

Financial commitment Running both compounds simultaneously involves significant ongoing expense

The overall incidence of AEs was similar between oral semaglutide and comparators (approximately 6080% of patients in any subgroup had an AE) and, as expected, gastrointestinal AEs (primarily nausea, vomiting and diarrhoea) made up a substantial proportion of the overall events for oral semaglutide