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These processes further potentiate ectopic fat deposition and worsen IR, creating a self-reinforcing cycle ( In summary, IR/hyperinsulinemia, hyperandrogenism, obesity, chronic inflammation, and OS engage in a complex, synergistic interplay

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This process occurs alongside impaired antioxidant defenses [397]

By affecting all these cellular functions already impaired in aging individuals it could explain why older, comorbid patients have the most severe outcomes with COVID-19 (312) and stimulate the use of GSH and Nrf2 enhancers as well as develop new therapies to protect mitochondria