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Dutch painters used cigarettes as a symbol of human foolishness in the 17th century and in the 19th century, cigarettes were perceived as props of fallen women and prostitutes
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Locche was far from a conventional world champion
As a proof of concept, and due to the relative ease of induction and assessment of differentiation in MSCs, the difficulty in obtaining organ-specific stem cells, and the fact that MSCs are recruited to sites of injury for tissue repair, the well-established model of MSC differentiation into osteoblast-like cells was used to assess the effects of smoke extracts on the differentiation potential of MSCs
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