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PMID 7866221

Dikalov S, Itani H, Richmond B, Vergeade A, Rahman SMJ, Boutaud O, et al

Contribution of Adipose Tissue Lipolysis to Nicotine and HFD-Induced Hepatic Steatosis Adipose tissue has the unique function of storing TG in lipid droplets and upon lipolysis, to provide FFA to other organs during time of energy shortage (47)

Tobacco smoking reduces p53, a tumor suppressor gene that is considered the genome guardian. Suppression of T-cell responses by Nicotine and tar is associated with decreased surveillance for tumor cells] reported that heavy smokers accumulate excess iron in hepatocytes which induces fibrosis and favors the development of HCC