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After stopping supplementation, some people may notice decreased energy levels, especially if their supplement regimen provided strong antioxidant support
Although additional studies are required to clarify the molecular mechanisms responsible for hyperhomocysteinemia-induced vascular disorders, there is evidence that the direct cytotoxicity of markedly elevated homocysteine and/or of its oxidized by-products (homocysteine thiolactone, homocysteine sulfinic acid, and homocysteic acid) damages endothelial cells (Dudman et al, 1991
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In women, this typically includes hip, thigh, and lower abdominal fat
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