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Carbon monoxide from cigarette smoke reduces the blood's capacity to carry oxygen, while nicotine causes blood vessels to constrict and the heart to work harder

To validate hippocampal hyperactivity in this sample of CHR-P individuals, we utilized data from 22 HC from a previous study [53], acquired with the same MRI scanner, scanning sequences, and acquisition parameters as the CHR-P sample (see Supplementary Methods)

But then they took me to a bar and a friend who was managing took us to a balcony, and there was everyone I have ever met in Los Angeles

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