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[279] [280] A third route starts with ethyl 3-oxobutanoate which through a double alkylation with methyl iodide followed by benzyl chloride can be converted into 2-methyl-3-phenyl-propanoic acid

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Our study found that, among adults, most never-smoking e-cigarette users were young, which is alarming considering the potential for long-term nicotine addiction and other health risks. For more information: Margaret Mayer, PhD, MPH, can be reached at [email protected].