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If you arent used to taking nicotine, you might feel: Dizziness Headache Racing heart Nausea / possible vomiting Stomach cramps Weakness People who use nicotine regularly build up a tolerance to the immediate short-term effects so after a while you might feel: Mild stimulation Increased ability to concentrate Relaxation Temporary reduction in the urge to smoke (or to vape) / not wanting to smoke as often How long it takes for nicotine to kick in and the time its effects last depend on how you take it