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Thus, T-cell accumulation causes chronic intestinal inflammation that can be treated with anti-IL-6 receptor antibodies ( Interleukin-13 (IL-13) as a mediator may be implicated in COPD progression, and inhibition of IL-13 prevents the pathogenesis of COPD ( Potential Mechanisms of the Skin-gut Axis Skin is composed of epidermis and dermis, which exerts the important roles in maintaining water and electrolytes homeostasis and providing an immune barrier (van Splunter et al., 2020)