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The infographic above shows the estimated average annual number of smoking-attributable deaths in the United States during 2005 through 2009 by specific causes, as follows: Total: more than 480,000 deaths Lung cancer: 137,989 deaths Other cancers: 36,000 deaths Heart Disease: 158,750 deaths Chronic Obstructive Pulmonary Disease: 100,600 deaths Stroke: 15,300 deaths Other diagnoses: 31,681 deaths Poison Center Calls Involving E-Cigarettes The number of poison center calls involving e-cigarettes went from one call per month in September 2010 to 215 calls per month in February 2014

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Global Next-Generation Cigarettes Market Forecast and Regional Outlook: Market Size & Growth Projections: 2025 Market Size: USD 56.49 billion 2026 Market Size: USD 65.13 billion Projected Market Size: USD 271.54 billion by 2035 Growth Forecasts: 17% CAGR (2026-2035) Key Regional Dynamics: Largest Region: Europe (46.7% Share by 2035) Fastest Growing Region: APEJ Dominating Countries: United States, Japan, United Kingdom, Germany, China Emerging Countries: India, South Korea, Indonesia, Vietnam, Philippines Last updated on : 12 March, 2026 Next-Generation Cigarettes Market - Growth Drivers and Challenges Growth Drivers Rising demand for smoke free alternatives: Due to the rising health concerns and desire to quit smoking, consumers increasingly choose smoke-free alternatives such as heated tobacco and nicotine pouches