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Specifically: Adults with a BMI of 30 or higher, or 27+ with a weight-related comorbidity (insulin resistance, hypertension, dyslipidemia) People who've plateaued on semaglutide or tirzepatide and are still short of their metabolic goals Those who are committed to a supervised protocol including labs, dosing adjustments, and dietary support Anyone with a longevity focus who understands that reducing visceral adiposity is one of the highest-leverage metabolic interventions available It is not a fit for people looking for a shortcut without lifestyle engagement

On the other hand, we identified a trend of methionine sulfoxide levels to be decreased in the serum of the mice treated with the combination treatment, which could represent a compensatory mechanism in response to the accumulation of homocysteine ( p = 0.051) (Supplementary Fig

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