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While both nutrients are generally safe when taken at recommended dosages, excessive intake can lead to potential side effects

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Compared with potent controls, ED men non-responders for oral sildenafil citrate showed significant decreases in the mean serum l-carnitine level (16.8 3.6 uM/L versus 66.3 11.9 uM/L, P = 0.001), the mean serum 25(OH)D level (21.2 7.1 ng/ml versus 54.6 7.9 ng/mL, P = 0.001) and IIEF-5 score (7.8 2.6 versus 23.9 1.3)

Similarly, acetaminophen overdose leads to the formation of a toxic metabolite, N-acetyl-p-benzoquinone imine (NAPQI), which depletes glutathione and induces oxidative stress in the liver [57]