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Diabetes 62, 18651875 10.2337/db12-1148 [DOI] [PMC free article] [PubMed] [Google Scholar] 39.Sinha, M.K., Raineri-Maldonado, C., Buchanan, C., Pories, W.J., Carter-Su, C., Pilch, P.F.et al

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Gopal Grandhige, MD, FACS, Board-Certified Surgeon Last Reviewed: March 28, 2026 Melanotan typically takes two to four weeks to produce visible changes in skin tone, with the most noticeable results appearing between weeks four and eight of consistent use