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Implementing standardized experimental protocols, including consistent plastic particle characterization, exposure duration, and cellular response metrics, will be essential in refining the scientific consensus on microplastic toxicity [60,62]

[83,89] Briefly, the reduced quantities of transported O2 and the decreased O2 supply to and uptake from the active tissues, combined with the binding of myoglobin by CO, significantly decrease maximal oxygen uptake (VO2max) reducing the functional capacity and the performance of the circulatory system ( Figure 2 )

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