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Additionally, a randomized, double-blind, placebo-controlled trial in 2,588 healthy older adults with mild hyperhomocysteinemia found that daily supplementation with 500 g of vitamin B 12 and 400 g of folic acid for two years reduced blood homocysteine concentrations but had no benefit on depressive symptoms in those with or without depressive symptoms at baseline (110)
Optimal Timing for Taking Vitamin B12 Supplements For individuals who require vitamin B12 supplementationwhether due to confirmed deficiency, dietary restrictions (such as veganism), or malabsorption conditions the timing of supplementation is generally flexible and should be guided by personal preference and tolerability rather than any specific metabolic advantage related to weight loss
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