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Participants who followed the full escalation schedule tolerated the compound significantly better than those in earlier trials where escalation was faster

133 For any breed, maximizing the chances of selecting a healthy dog includes: Choose a dog from a breeder that tracks the overall health of all their dogs and uses this health data to select individuals for their breeding programs with the lowest probability of passing down undesirable genetic traits to their offspring

For example, PtdIns4P was suggested to have a direct role in the anchoring of the protein complex-bound CtBP1-S/BARS (Valente et al., 2013)