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While 5-HT4 agonists enhance gastric accommodation and gastric emptying, 5-HT3 antagonists had no significant effect on these functions, and 5-HT 1A agonists enhance gastric accommodation and tend to slow gastric emptying ( Studies focusing on IBS have shown that circulating 5-HT levels rise after a meal, and that this rise is exaggerated in IBS with diarrhea and suppressed in IBS with constipation (112, 113)