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The trade-off is that glucagon agonism is the arm most likely to nudge metabolic parameters in directions that need watching (heart rate and glycemic dynamics among them), which is another reason the documented protocol climbs slowly and why the class monitoring guidance below is not optional context

This omission limits pharmacological context, hinders potency normalization across studies, and constrains the prioritization of peptide leads for translational development [177, 178]

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