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Results Impaired glucose tolerance in a -cell specific EGFR null mouse Male pdx1-creERT;EGFR fx/fx mice (Cre + ) and control Cre ;EGFR fx/fx mice received exendin-4 (Cre + Ex + and Cre Ex + ) or saline injection (Cre + Ex and Cre Ex ) for 5 days starting at 8 weeks of age, 2 weeks after tamoxifen treatment

Although these agents share a common mechanism of action, their considerable structural heterogeneity may lead to distinct pharmacological characteristics

However, it requires significantly higher doses (1620mg subcutaneous implant every 60 days) and does not cross the blood-brain barrier

Others inhibit its expression or post-translational modifications (Fig