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Additionally, another study reported elevated protein levels of HSP60, HSP27, HSP90, HSC70, and GRP94 in people with obesity compared to lean controls [100]

Overexpression of HK2 not only accelerates glucose uptake, but also activates multiple pathways required for glucose influx into Kras-driven PC growth, including the pentose phosphate pathway, serine synthesis pathway, and hexosamine biosynthesis pathway, which protomes the proliferation, invasion, and metastasis of PC (46, 47)

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Simultaneously, its GLP-1 receptor agonist activity stimulates insulin release, suppresses glucagon secretion, slows gastric emptying, and reduces appetite