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The protective effects of GLP-1 RAs against cardiovascular events have been demonstrated in several studies, thus supporting their application in patients with heart failure with preserved ejection fraction and DM2 ( Taken together, GLP-1 is a major metabolic and regulatory hormone, with many potential therapeutic implications beyond glycemic control, encompassing cardiovascular protection, enhanced renal function, and the potential benefits in hepatic disease
Classical cirrhosis is rare in rodents in contrast to dogs and humans and cannot reliably or consistently separate from a robust fibrotic reaction with associated nodular regeneration, oval cell proliferation, and bile duct hyperplasia
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