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Front Endocrinol (Lausanne) (2021) 12:735824

There's no evidence that higher doses produce proportionally better results

for the treatment of chronic kidney disease in patients with polycystic kidney disease or patients requiring or with a recent history of intravenous immunosuppressive therapy or greater than 45 mg of prednisone or equivalent for kidney disease as Jardiance is not expected to be effective in these populations