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Some cases occur sporadically with an unknown etiology (32)

In vitro , liraglutide dose-dependently downregulates pro-inflammatory mediators such as Mcp-1 and Cd38 in LPS-activated RAW264.7 macrophages, while simultaneously upregulating Erg-2, an M2-specific transcription factor (Yu et al., 2019)

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Research using the Broad Institute's Connectivity Map found that GHK-Cu influences the expression of over 4,000 human genes - including many involved in repair, anti-inflammatory response and extracellular matrix maintenance