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Clinical evidence indicating accelerated antidepressant response, improved cognition, enhanced sleep architecture, and reduced biomarkers of neuronal injury in elderly and medically comorbid populations underscores its relevance in late-life depression and depression associated with cognitive or vascular dysfunction (96)

However, issues with graft survivability, disease transmission, and integration have motivated tissue engineers to develop newer composite scaffolds that guide localized regeneration of the cartilage and bone layers of an osteochondral unit

A cleft palate may just be an opening at the back of the mouth, or it may be a split in the palate that runs all the way to the front of the mouth