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1.2 Adverse Outcome Pathways and Aggregate Exposure Pathways The AOP offers a structured framework to illustrate the underlying biological mechanisms, connecting a molecular initiating event (MIE) through a series of key events (KE) up to the occurrence of an adverse outcome (AO) at the organism or population level ( 1 This knowledge can be further consolidated by organizing these pathways into an AOP network (AOPN), which enables the integration of mechanistic information related to different stressors within a single, structured framework

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